Overexpression of Transcriptional Coactivator Leads to Mightier Mice
Zoltan Arany, MD, and colleagues overexpressed the transcriptional coactivator PGC-1ß in the skeletal muscles of mice to develop animals that run for longer and at higher workloads.
View ArticleLifestyle and Age-Related Macular Degeneration Risk
Debra A. Schaumberg, ScD, OD, MPH, and colleagues found genetic predisposition and exposure to modifiable risk factors such as obesity and smoking can multiply the risk for age-related macular...
View ArticleNeurodegeneration in Fruit Flies Reversed with Vitamin E
Dora Dias-Santagata, PhD, and colleagues discovered in fruit fly models that neurodegeneration can be reversed through the genetic and pharmacologic manipulation of antioxidant defense mechanisms.
View ArticleResearchers Isolate and Expand Tregs
Rachael A. Clark, MD, PhD, and Thomas S. Kupper, MD, became the first pair of researchers to isolate and expand regulatory T cells (or Tregs) from normal human skin.
View ArticleNovel Gene Discovered for Wilms Tumor
Miguel N. Rivera, MD, and colleagues discovered that deletions and mutations in a second gene, WTX, are found in a large fraction of Wilms tumors (nearly 30 percent).
View ArticleNew Molecular Target for RA Treatment
Michael B. Brenner, MD, and David M. Lee, MD, PhD, observed that mice that lacked the cell adhesion molecule cadherin-11 inadequately formed the culprit joint lining, or synovium, which overgrows in...
View ArticleFoxOs Mediate Blood Stem Cell Resistance to Oxidative Stress
Gary Gilliland, PhD, MD, and Zuzana Tothova found that a family of transcription factors mediate blood stem cell resistance to physiologic oxidative stress, and that deleting these proteins jeopardizes...
View ArticleGenes That May Lead to Developmental Disorders Discovered
Researchers as part of the Developmental Genome Anatomy Project (DGAP) found two additional genes that when disrupted, may lead to the development of specific physiological conditions.
View ArticleVariability Among Clinicians in the Determination of Upper Lobe-Predominant...
Craig P. Hersh, MD, MPH, and Edwin K. Silverman, MD, PhD, and colleagues evaluated the agreement between radiologist and pulmonary physicians in terms of determining whether a patient has upper...
View ArticleGlobal Survey of the Consequences of small and large DNA variants in our Genome
Findings published in Science will accelerate the search for genes involved in human disease, providing a first genome-wide view of how the unique composition of genetic variation within each of us...
View ArticleKPF Boosts Metabolism in Human Skeletal Muscle Cells
Antonio C. Bianco, MD, PhD, and colleagues observed a 30 percent increase in energy expenditure in human skeletal muscle cells treated with kaempferol (KPF), a flavonol found in foods such as apples,...
View ArticleWhole-Grain Cereal Decreases Heart Failure Risk
Luc Djousse, MD, MPH, DSc, and J. Michael Gaziano, MD, observed a 28 percent decrease in the risk of developing heart failure in people who ate whole-grain breakfast cereal seven or more times per week...
View ArticleSoros Joins Health Groups to Battle Drug-Resistant TB, HIV Explosion
George Soros and leading health organizations today announced funding to develop a groundbreaking treatment program for people with drug-resistant tuberculosis and HIV/AIDS in poor countries. This...
View ArticleVitamin D Insufficiency and Prostate Cancer Risk
Haojie Li, MD, PhD, and colleagues from the Channing Laboratory observed that a large portion of men had less than optimal blood levels of vitamin D, and that this insufficiency increased their risk...
View ArticleClinical Trial Offers Minimally Invasive Procedure for Heart Valve Leak
Brigham and Women’s Hospital (BWH) is currently participating in the nation-wide EVEREST II clinical trial for patients with a serious heart condition known as mitral regurgitation (MR).
View ArticlePostmenopausal Hormone Therapy and Risk of Cardiovascular Disease
Previous studies have suggested that the effects of hormone therapy on risk of cardiovascular disease may differ between younger and older women. A new combined analysis of the two major hormone...
View ArticleMEMS Device Helps Researchers Align Cells
Researchers developed a microelectromechanical system (MEMS) that allows cell biologists to manipulate the distance between mammalian cells in laboratory experiments without the use of microscopes or...
View ArticleMartin A. Samuels, MD, Receives H. Houston Merritt Award and Lecture from AAN...
The American Academy of Neurology (AAN) is awarding the 2007 H. Houston Merritt Award and Lecture to Martin A. Samuels, MD, DSc (hon), MACP, for his insights related to how the nervous systems affects...
View ArticleReducing Dietary Salt Lowers Cardiovascular Disease Risk
Researchers at Brigham and Women's Hospital, in a follow-up trial, found that reducing sodium intake among men and women lowered subsequent risk of cardiovascular disease by 25 percent more than 10...
View ArticleBrigham and Women's Hospital to Lead Phase III Clinical Trial for New Class...
Brigham and Women's Hospital announced today that it will lead a large-scale global phase III clinical trial for a new class of anti-platelet heart medication for patients who have had a heart attack,...
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